The bulk of the collection consists of histories and geneaologies of the Webb and Daniel families of North Carolina, going back to the 18th century. Materials include drafts of historical research, memoirs, clippings, pamphlets, programs, 20th century photographs, and many folders of Webb family correspondence dating from the 20th century. Family history material comprises primarily incoming and outgoing family correspondence and geneaological records (1845-2001) for the Webb, Daniel, Smith, and Stinson families and others. Some of this material was gathered by Webb's father, J. W. Webb, for his book, Our Webb Kin of Dixie. Also includes Webb's 1941 doctoral thesis and other school records (1925-1933); as well as binders and scrapbooks compiled by Webb detailing her youth and schooling, private practice and hospital career, international trips, Durham history, and various ancestors and relatives, including N.C. judge Susie Marshall Sharp, James E. Webb, and Stephen Moore.
Papers also include memoirs, largely in verse and written by Webb's grandmother, about slaves on her father's plantation; and an album of sayings related to "Poplar Forest," a home built by Thomas Jefferson, where a relative lived in 1970. The album's cover has an early photograph of the house pasted on. There is also a small amount of information on the histories of Wilson and Wright high schools in North Carolina and a few church histories as well.
Other folders making up approximately a quarter of the collection contain Bailey Webb's professional correspondence and papers relating to her career as a pediatrician and medical community leader in various towns and cities of North Carolina. Correspondents include members of the Trent and Semans families. Includes Webb's diplomas, typewritten memoirs of her career, begining with her medical school training at Duke in the 1940s. A few of these volumes contain patient information and photos - these are currently closed to use.