The Women's Center serves the Duke undergraduate, graduate and professional student communities. The center supports and promotes student women and gender issues on campus. Materials present include subject files, correspondence, memoranda, reports, proposals, surveys, programming records, committee records, flyers, job descriptions, training materials, photographs, slides, videocassettes, and other materials relating to the history and daily operation of the Center.

The Women's Center records contain subject files, correspondence, memoranda, reports, proposals, surveys, programming records, committee records, flyers, job descriptions, training materials, photographs, slides, videocassettes, and other materials relating to the history and daily operation of the Center. Major subjects include sexual assault, crime prevention, safe sex, gender issues, sorority life, harassment, and women in science and engineering. Materials can also be found on the following groups or programs: BASES (Building Awareness through Shared Experiences); DARE (Duke Acquaintance Rape Education); GPWN (Graduate and Professional Women's Network); MAC (Men Acting for Change); SASS (Sexual Assault Support Services); Take Back the Night; VOICES (magazine published by the Women's Center); WISE (Women in Science and Engineering); Women of Color; and the Women's Center Art Gallery.

The collection also contains images and text from the "Breaking Out" exhibition. Exhbit materials consist of women sharing stories about sexual violence and harassment. The exhibit was created by students and co-sponsored by the Women's Center. Materials in the collection range in date from 1970-2014.