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Virginia Barber became a literary agent in 1971 and opened her own agency in 1974. The Virginia Barber Literary Agency was sold to the William Morris Agency in 2001. Among the authors she represented have been Rosellen Brown, Andrew Delbanco, James Dodson, Sue Monk Kidd, Peter Mayle, Alice Munro, David Nasaw, Anita Shreve, and Anne Rivers Siddons. She has served on the Board and as President of Women's Media Group and on the Boards of Literacy Partners, Duke University Libraries, and Poets and Writers. The collection includes client files and correspondence for the VBLA's many clients during the late 1970s through the early 2000s. There are also legal and financial materials, correspondence files with other agencies and publishers, including Virago Books, and materials from Barber's work with professional organizations such as the Independent Literary Agents Association. Notable clients represented in this collection include Peter Mayle, Anita Shreve, MacDonald Harris, and Paul Ehrlich.

Virginia Bryan was Assistant Dean of the Woman's College and a botanist. The collection includes correspondence, notes, field notebooks, article reprints, and other materials related to Virgnina Bryan's work as a botanist.