Includes correspondence; a memorandum of agreement between Pickens and David Files regarding a loan from Pickens to Files; financial papers relating to the operation of Pickens' plantation in Alabama; a mortgage bond; and an Agricultural Memorandum Book (1822-1826) which discusses the clearing of land for planting cotton and corn, describes the seeds he used, and includes several pages of accounts. Pickens also comments on his visits to Cahaba, Alabama, and the flood which occurred while it was the state capitol.