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Ledger contains numerous additions laid in. Alphabetical index to ledger is included but bound as a separate volume.

William Hyde Jr.'s financial transactions with William Hyde & Son from 1853-1870 appear at the end of the volume.

This folder contains various loose documents that were removed from the day books, including a foolscap bearing sums owed and names of clients and three drafts of an 1861 petition to the U.S. Congress requesting that the Crittenden Compromise be adopted by all states in order to peacefully preserve the Union. Of related interest is a page bearing biblical passages regarding enslaved persons.

Daily entries are usually brief and focus on who Spalding dined with or visited, but there are other entries detailing medical lectures and other medical school experiences, dinner conversations, events in London, and his own illness. Includes expenses, amusements attended, a list of books, and letters sent out.